Fig 1: Effects of sepsis on the composition of the mitochondrial calcium uniporter complex (mtCU) in animal and cellular experiments. (A–B) Western blotting analysis of the effects of CLP modeling on MICU1, MICU2, MCU, EMRE, and GAPDH in mice tibialis anterior (TA) muscles, n = 3. (C) Effects of sepsis on the MICU1:MCU ratio in TA muscles of mice. (D–E) Effects of 5 μg/mL LPS intervention on the components of MCU in C2C12 cells, n = 3. (F) Effects of LPS on the MICU1:MCU ratio in C2C12 cells, n = 3. (G–H) Gene expression of MCU in mice and C2C12 cells, n = 3. Data are shown as mean ± SEM. *P < 0.05 compared with the sham group (control group), ▲P < 0.05 compared with the 6-hour intervention group, and ◆P < 0.05 compared with the 12-hour intervention group.
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